Chordopoxvirus protein F12 is an inactivated homolog of Family B DNA polymerases In the course of a survey of the evolutionary provenance of poxvirus proteins, we unexpectedly observed that PSI-BLAST searches against the non-redundant database (NCBI, NIH, Bethesda) initiated with the amino acid sequence of Vaccinia virus (VACV) protein F12 (GenBank Accession No Q80HX6 ) detected, in addition to the highly significant similarity to the homologs from all chordopoxviruses, a marginal, not statistically significant similarity to several identified or putative DNA-dependent DNA polymerases (DNAPs) from plant and fungal mitochondrial plasmids and bacteriophages.
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Chordopoxvirus protein F12 implicated in enveloped virion morphogenesis is an inactivated DNA polymerase.
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