Barely Significant
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Chemoselective activation of sp(3) vs sp(2) C-H bonds with Pd(II).

J Am Chem Soc · 2015 · PMC4304446 · PMID 25423164

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highly significantno p-value reported
1 C–H activation is highly significant because additional steps to preactivate a center for bond construction (e.g., halogenation) can be avoided, thereby increasing efficiency by reducing step-count and decreasing waste.

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