Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants.

However, Sanacora et al later found that effective cognitive behavioral therapy treatment led to a nonsignificant trend toward a reduction in OCC GABA concentrations, 26 while Bhagwagar et al showed that OCC GABA concentrations in recovered MDD patients were still reduced compared to healthy controls. 27 , 28 These differing results may reflect methodological differences in the detection of GABA, 25 brain region-specific relationships between GABA concentrations and depression, or differences in the mechanism of antidepressant treatments.

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