Medical closure of patent ductus arteriosus does not reduce mortality and development of bronchopulmonary dysplasia in preterm infants.

Those patients with significant hemodynamic changes may present congestive heart failure or in the long-term may develop irreversible changes in pulmonary vascularity leading to pulmonary hypertension.[ 9 ] There may be significant co-morbidity including pulmonary edema and bleeding, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) bleeding, necrotizing enterocolitis (NEC), feeding intolerance and retinopathy of prematurity (ROP).[ 9 ] However, in recent articles the effect of ductus closure on mortality and

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