Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells.

Notably, their finding of accumulation of glucose-6-P and key metabolites of the PPP (6-phosphogluconate and ribose-5-P) as a major discriminator between GBM and low-grade gliomas corresponds with our data, showing a highly significant and time-dependent increase of these metabolites in hypoxic GBM cells (Fig. 1 and 2 ).

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