Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin.

Despite the highly significant mitigation of dermonecrosis, however, the bacterial burdens of the PND-Ig and Control-Ig treated mice were not statistically different until days 5 and 6, whereupon the PND-Ig group demonstrated significant reductions in bacterial burden compared to the Control-Ig group of mice ( p = 0.046, day 5; p < 0.0001, day 6, Fig. 9B, 9D ).

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While mice treated with Ab against the PND were significantly protected from dermonecrosis when lesion areas were assessed at day 3, mitigation of bacterial proliferation was marginally significant at day 5 and was highly significant by day 6.

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