Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in mice.

The possibility that deficient expression of Igf1 in osteocytes may promote calcium deficiency-induced bone resorption is further supported by the marginally significant (P = 0.064) genotype effect ( Fig. 3A ).

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Consistent with a previous report that calcium deficiency reduced circulating levels of FGF-23 [ 37 ], the two-week dietary calcium restriction led to highly significant reduction in the plasma level of FGF-23 in WT control mice and in cKO mutants ( Table 2 ).

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