cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1.

J Mol Cell Cardiol · 2015 · PMC4312355 · PMID 25446180

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Forskolin stimulation resulted in a transient but significant stimulation of CCN1 mRNA levels at 1 h but a dramatic and highly significant inhibition after 2 h (to 2.6 ± 1.05% of controls) and 4 h (to 2.4 ± 6.6% of controls) ( Fig. 2 C).

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