a marginal trendp -value = 0.058
The analysis underlying these conclusions was not presented, but the statistical results presented in the full study report ( Hazleton Laboratories 1983 ) support the interpretation of these data as indicative of a marginal trend (trend p -value = 0.058) with statistically significant increases in three of the four dose groups ( p = 0.071, 0.023, 0.019, and 0.036 for the 50, 125, 185, and 250 mg/kg/day dose groups, respectively).