10 , 11 , 12 Once an increasing trend of circulating EBV DNA is detected, reduction or withdrawal of immunosuppression should be instituted. 8 Because most cases of EBV+ PTLD post HSCT involve CD20+ B cells, the preemptive use of rituximab has been shown to abort the development of clinical disease. 8 , 12 , 13 However, when PTLD has developed, the use of rituximab and chemotherapy is less effective.
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Epstein Barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target.
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