Antinociceptive effect of clavulanic acid and its preventive activity against development of morphine tolerance and dependence in animal models.

RESULTS Acetic acid-induced writhing test In acetic acid-induced writhing test, clavulanic acid at doses of 10 and 20 mg/kg significantly ( p <0.05) inhibited acetic acid-induced abdominal constrictions and a highly significant decrease was seen at dose of 40 mg/kg ( p <0.001).

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