Barely Significant
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Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung.

PLoS One · 2015 · PMC4319729 · PMID 25658421

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a possible trendno p-value reported
This supports a possible trend in the reduction of OX/ROS in the presence of nicotine because the aerosols produced from the Blu e-cig cartomizer containing 16 mg nicotine exhibits a significant reduction in OX/ROS compared to the nicotine free cartomizer.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.