ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2.

J Exp Med · 2015 · PMC4322049 · PMID 25646266

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highly significantno p-value reported

Using our protein-based immunization system and the same method of CXCR5/Bcl-6 coexpression analysis, we are able to fully reproduce these results with a highly significant difference in CXCR5/Bcl-6 double-positive cells in ICOS KO compared with WT mice and reduced Bcl-6 levels of ICOS KO T cells compared with WT CXCR5 high T cells (unpublished data).

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