Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology.

That these may be significant problems comes from 2 lines of thinking: first, non-neuronal cells lack many of the most important pathways that make neurons unique (including their ability to propagate an action potential, their large size, their extensive connectivity, their ability to convert an electrical signal into a chemical signal at neural synapses, and their extreme compartmentalization into biochemically distinct axonal and somatodendritic regions) and, second, euphemistically, humans are not just big mice [e.g., 2 – 4 ].

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