MBL-II-141, a chromone derivative, enhances irinotecan (CPT-11) anticancer efficiency in ABCG2-positive xenografts.

In the liver, SN-38 followed a similar profile as in the blood, but the increase observed in the presence of MBL-II-141 was barely significant (Figure 3B and Supplementary Table 3 ), while SN-38 levels in the brain were below the limits of quantification (Figure 3C ).

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