highly significantP < 2 × 10 −6
The functional annotation analysis of Ang II–dependent transcriptome using DAVID database 11 revealed highly significant enrichment for genes associated with blood vessel development ( P < 2 × 10 −6 ), angiogenesis ( P < 7.9 × 10 −6 ), positive regulation of proliferation ( P < 0.002), and several associated signaling pathways, including cytokine–cytokine receptor interactions ( P < 0.0076), transforming growth factor-beta pathway ( P < 0.01), notch signaling ( P < 0.02), and protein kinase activity ( P < 0.025) (Fig. 1 ).