The mutated DXR genes that showed synthetic growth defects with top2-191 were clustered into three major classes with an increasing trend of synthetic growth defect, as depicted by the negative G.I. scores ( Fig. 2B, C ; C-III (red), C-IV (blue) and C-V (purple) blocks).
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Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.
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