Barely Significant
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Comparison and efficacy of LigaSure and rubber band ligature in closing the inflamed cecal stump in a rat model of acute appendicitis.

Biomed Res Int · 2015 · PMC4324495 · PMID 25699264

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an increasing trendno p-value reported
Furthermore, the study indicated an increasing trend of serum TNF- α in BR subgroup, and we believed that rubber band related foreign body reaction might cause persistently increased TNF- α in BR subgroup.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.