Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T.

While the K118C mutation caused clear gel mobility change that may reflect tertiary structure changes affecting the binding of SDS [29] , we detect only a small trend of local conformational change in cTnI K118C mutation using mAb 4B7 and no remote change was detected with mAb 4H6.

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