The prognostic and predictive value of Tregs and tumor immune subtypes in postmenopausal, hormone receptor-positive breast cancer patients treated with adjuvant endocrine therapy: a Dutch TEAM study analysis.

Breast Cancer Res Treat · 2015 · PMC4326646 · PMID 25616355

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a statistical trendno p-value reported

A statistical trend was seen for the interaction between endocrine treatment and tumor IS in the multivariable interaction model ( p value RFP: 0.15, BCSS: 0. 19 and OS: 0.17).

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highly significantno p-value reported

Our data suggest a positive effect of Treg presence on overall survival outcome in the sequentially endocrine-treated patient group, which is further supported by a highly significant interaction term for endocrine treatment and Treg presence.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.