Superoxide inhibits guanine nucleotide exchange factor (GEF) action on Ras, but not on Rho, through desensitization of Ras to GEF.

Biochemistry · 2014 · PMC4327825 · PMID 24422478

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hardly significantno p-value reported

The inhibition of the rate constant and span of the Cdc25-mediated C118S Ras GDP dissociation by O 2 •– was hardly significant (Table 1 ).

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