Tumor cell targeting by iron oxide nanoparticles is dominated by different factors in vitro versus in vivo.

In contrast, following normalization to blood iron concentrations, the tumor tissue accumulation of the targeted 30 nm IONP-Tfab and IONP-PEG-Tfab were highly significant relative to the PBS control group (P<0.001, S7A Fig .), and this observation demonstrates that the antibody directed 30 nm IONP specifically localized to tumor tissue following systemic administration in the mouse BT-474 xenograft model.

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