Barely Significant
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Quantifying the entropy of binding for water molecules in protein cavities by computing correlations.

Biophys J · 2015 · PMC4336375 · PMID 25692597

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may be significantno p-value reported
At the same time, it will also be important to estimate the S vol term explicitly, as it may be significant and vary between buried and surface-exposed hydration sites.

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