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Time trends of period prevalence rates of patients with inhaled long-acting beta-2-agonists-containing prescriptions: a European comparative database study.

PLoS One · 2015 · PMC4338187 · PMID 25706152

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an increasing trendno p-value reported
Following a standardised protocol, we found an increasing trend for the period prevalence rate of patients with LABA-containing prescriptions in all five countries, and this was most pronounced in patients diagnosed with COPD even after age- and sex-standardisation.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.