Early cerebral small vessel disease and brain volume, cognition, and gait.

Lower MoCA score was associated with only a nonsignificant trend toward lower gray matter volume ( p = 0.07).

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For every additional 10 years of age, the cerebral cortex was 0.026mm thinner (95% CI = 0.019–0.033); changes were seen throughout much of the lateral frontal and posterior temporal and parietal cortices ( Fig 2 ), with the most highly significant changes in the medial and dorsolateral frontal, posterior temporal, and parietal cortices.

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