High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.

Am J Clin Nutr · 2015 · PMC4340065 · PMID 25733650

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0580

boldest claim

The sentences

borderline significanceP = 0.057so close (0.05 < p ≤ 0.1)

Concentrations of PCho, a choline storage form and intermediate in the cytidine-diphosphocholine (CDP) choline pathway for PtdCho synthesis, were also significantly lower due to the Mthfr +/− genotype, as were the concentrations of PtdCho and its catabolite SM, with borderline significance for another catabolite, LysoPtdCho ( P = 0.057).

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borderline significantP ≤ 0.058so close (0.05 < p ≤ 0.1)

Unless noted, data were analyzed by using 2-factor ANOVA with diet and genotype as the independent variables, followed by post hoc analysis by Tukey to correct for multiple comparisons if the interaction term was significant or borderline significant ( P ≤ 0.058 where indicated).

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