Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options.

Retrovirology · 2015 · PMC4340294 · PMID 25756928

Europe PMC DOI

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highly significantno p-value reported

Overall these results are highly significant in HIV infection considering the failure of blockade of a related co-inhibitory molecule CTLA-4 to expand virus-specific CD8 + T cells during chronic SIV infection and to reduce plasma viral load in SIV-infected macaques [ 127 ].

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