Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans.

Despite the small sample size, many of the intervention effects in the proteomics pathway analyses and for individual proteins were highly significant, exceeding by orders of magnitude, the Bonferroni corrections and the effects observed in multiple previous analyses we have performed in which we compared plasma samples in cancer cases and controls [ 23 , 26 , 27 ].

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