Co-stimulation with rIL-2 led to increase of the proportions of functional Tregs in progressive RA patients and controls; in MTX patients, its increase was of borderline significance compared to anti-CD3-stimulated cells.
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Exogenous IL-2 controls the balance in Th1, Th17, and Treg cell distribution in patients with progressive rheumatoid arthritis treated with TNF-alpha inhibitors.
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