Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging.

Neural Regen Res · 2012 · PMC4345661 · PMID 25737702

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a decreasing trendno p-value reported

With increasing age, the number of rearings in each group exhibited a decreasing trend after the initial peak at 18 months.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.