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Early metacarpal bone mineral density loss using digital x-ray radiogrammetry and 3-tesla wrist MRI in established rheumatoid arthritis: a longitudinal one-year observational study.

Arthritis · 2015 · PMC4346684 · PMID 25785197

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an increasing trendno p-value reported
There has been an increasing trend towards using these in clinical trials with comparison made to changes on radiographs [ 21 – 23 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.