Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis.

PLoS Pathog · 2015 · PMC4349736 · PMID 25738568

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a decreasing trendno p-value reported

The absence of AMPK and SIRT1 led to a significantly reduction of the parasite load in all tested organs, except for the spleen of SIRT1 KO mice that showed a decreasing trend ( Fig. 7C-E ).

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