Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma.

PLoS One · 2015 · PMC4349806 · PMID 25739030

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Cox Proportional Hazards Models When the imaging biomarkers were analyzed independently in separate univariate models for overall survival ( Table 2 ) in Cohort 1, we noted statistically significant associations with tumor volume (HR = 2.59; 95% CI 1.06–6.29) and convexity (HR = 0.34; 95% CI 0.14–0.82), and a borderline significant association with entropy ratio (HR = 2.19; 95% CI 0.94–5.08).

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