Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.

Within the 5' promoter CpG island, there was a highly significant positive correlation between 5-mC and 5-hmC as shown in Figures 3c ( r =0.77, P =0.002) similar to the positive relationship observed globally in the cerebellum ( Figure 2b ).

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A marginally significant correlation ( P =0.08) was observed between 5-hmC and 8-oxo-dG in autism ( Figure 2d ) but not control cerebellar samples ( Figure 2c ). 5-hmC level within the upstream EN-2 CpG island promoter and gene body In our initial epigenetic evaluation of the developmentally regulated EN-2 gene, we reporte

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