Data analysis showed a tendency toward significance of the association between pre-treatment Phe at diagnosis and the rapidity of response, being lower Phe levels better predictors of a response to BH4 within the first 24 h of the test [Phe at diagnosis (mean ± SD) in rapid responders 853 ± 450 micromol/L; Phe at diagnosis (mean ± SD) in slow responders 1305 ± 500 micromol/L; p = 0.057].
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Long-term follow-up of patients with phenylketonuria treated with tetrahydrobiopterin: a seven years experience.
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