Effect of in vivo loading on bone composition varies with animal age.

The endosteal and periosteal regions of both the loaded and control limbs of the 10, 26 and 78 week old mice had lower mineral:matrix ratio ( Figure 5 ) and crystallinity (with few, marginally significant exceptions: p=0.07 for loaded limbs of 26 week old and p=0.06 for control limbs of 78 week old, for periosteal versus intracortical region comparisons) and higher acid phosphate than the intracortical region.

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