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Fertility, pregnancies and outcomes reported by females with common variable immune deficiency and hypogammaglobulinemia: results from an internet-based survey.

J Clin Immunol · 2015 · PMC4352195 · PMID 25572592

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an increasing trendno p-value reported
There was also an increasing trend in their concern about losing the pregnancy (from 37 to 66 %) from first to subsequent pregnancies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.