highly significantP = 6.61 × 10 −5
The divergence within each group is not statistically significant (divergence within CQS subsets Wilcoxon test, P = 0.35- Figure 2 C; within CQR subsets Wilcoxon test, P = 0.43- Figure 2 D), while the divergence between the groups is highly significant (Wilcoxon test P = 6.61 × 10 −5 , Figure 2 A and B).