Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.

J Exp Med · 2015 · PMC4354372 · PMID 25687282

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highly significantno p-value reported

The shift of PLZF from bivalency to monovalency during iNKT cells differentiation is gene specific and highly significant as revealed by quantitative PCR-based analysis of H3K27me3 and H3K4me3 levels at the PLZF promoter in preselection DP and thymic iNKT cells ( Fig. 1 D ).

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