Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes.

The presence of the BRS-3 ligand elicited a stimulation of glucose transport [with respect to the value obtained in the cells incubated in the absence of the peptide (15.7±2.4 fmol/2×10 4 cells, n=4)], which was almost significant (p=0.082) following treatment with the ligand at 10 −12 M (20.8±1.4 fmol/2×10 4 cells, n=4), reached a maximal level at 10 −11 M (25.1±1.4 fmol/2×10 4 cells, n=4, p<0.001), and was thereafter maintained up to the dose of 10 −8 M (overall mean value: 23.7±1.1 fmol/2×10 4 cells, n=4, p<0.008), and then slightly decreased by treatment at 10 −7 M (20.4±1.1 fmol/2×10 4 cells, n=4).

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