Physicochemical evolution and molecular adaptation of the cetacean osmoregulation-related gene UT-A2 and implications for functional studies.

In the program testing, universal genetic codes, the HKY85 evolution model and 31 quantitative biochemical properties were used to estimate adaptive selection (referred to as positive destabilizing selection, when the frequency of changes in magnitude categories 6, 7 and 8 were highly significant, z-scores > 3.09 and P < 0.001).

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