Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.

In slices from Fmr1 KO mice (C57BL6J background), application of DHPG strongly reduced EPSC amplitude (EPSC measured 45 min after DHPG: 56 ± 5% of control, mean ± SEM, n = 7; Figure 2C ), with a highly significant reduction with respect to control EPSC ( P < 0.00001, Figure 2D ).

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