Pathway analysis of genes with POL II binding sites in MCF7HER2 (606 genes) using Database for Annotation, Visualization and Integrated Discovery (DAVID) [ 24 ] bioinformatics produced a list of five highly significant gene ontology (GO) terms (Benjamini score 8.20E-07 to 9.5E-04) focused in five main functions, homeobox, developmental, kinase, tyrosine protein kinase and phosphotransferase.
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A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors.
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