Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes.

Elife · 2014 · PMC4359381 · PMID 25237741

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highly significantno p-value reported

Therefore it is highly significant that other nucleosome free regions, such as ARS are not targeted by the deaminases, despite undergoing DNA melting during the initiation of replication.

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