International trends in primary liver cancer incidence from 1973 to 2007.

However, an increasing trend of PLC incidence rates was seen in most of these populations which were partly due to the widespread HCV infection associated with drug use, exposure to contaminated blood transfusion and/or needles used for medical purposes [ 36 ].

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In addition, females in Poland (from 1973–1977 to 2003–2007) and males in Spain (from 1982–1987 to 2003–2007) also exhibited a decreasing trend of PLC incidence rates.

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