Long-term safety and efficacy of tobramycin in the management of cystic fibrosis.

Ther Clin Risk Manag · 2015 · PMC4362982 · PMID 25792839

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an increasing trendno p-value reported

30 , 31 In EVOLVE, after three consecutive treatment cycles, an increasing trend of resistance to tobramycin compared with baseline was observed in the group of patients treated with TIP.

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