Exome sequencing in an admixed isolated population indicates NFXL1 variants confer a risk for specific language impairment.

By contrast, the combined allele frequency of these three variants in 4679 independent European controls (from the 1000 genomes and EVS public databases) is 0.47%, a difference that yields a marginally significant P -value of 0.029 (4 of 234 SLIC chromosomes vs 44 of 9358 control chromosomes).

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