Barely Significant
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In vitro matured oocytes are more susceptible than in vivo matured oocytes to mock ICSI induced functional and genetic changes.

PLoS One · 2015 · PMC4364773 · PMID 25786120

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highly significantno p-value reported
Importantly, highly significant, distinct H2AX phosphorylation triggered by mock ICSI was observed in IVM oocytes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.