A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females.

Nat Commun · 2015 · PMC4365504 · PMID 25784220

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highly significantno p-value reported

When we applied the TDT-HET method to the markers in the candidate region for the same pedigrees, our multi-locus P -value became highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.