borderline significantP =0.0582
The covariate-adjusted reduction in mean number of severe exacerbations for the roflumilast-treated group exhibited a borderline significant difference ( P =0.0582) and favorable comparison with the covariate-adjusted change in severe exacerbations for the non-roflumilast-treated group (parameter estimate, −0.1801; 95% CI −0.3664, 0.0062).